Hawaii News

University of Hawai‘i researchers: Gut bacteria linked to mental health, disease risks

Listen to this Article
4 minutes
Loading Audio... Article will play after ad...
Playing in :00

A potential link between intestinal bacteria and the disproportionately higher rates of certain chronic disease and mental health risks among Native Hawaiians and other Pacific Islanders has been discovered by researchers from the University of Hawaiʻi at Mānoa.

The new findings were published in a series of articles in Frontiers, the world’s third most-cited research publisher.

Researchers from UH Mānoa’s John A. Burns School of Medicine and the University of Hawaiʻi Economic Research Organization in the College of Social Sciences have identified key differences in the numbers and types of intestinal bacteria strains in Native Hawaiians and other Pacific Islanders that track with age, type 2 diabetes status, body mass index and self-esteem.

Using these profiles, the researchers identified specific features that may partially regulate the biological processes that impact mental health and metabolic conditions that appear to be related to inflammation, and may help explain the higher incidences of depression and diabetes among Native Hawaiians and other Pacific Islanders.

PhD student Brennan Yamamoto performs a type 2 diabetes test on a sample from a study participant. Photo Courtesy: University of Hawai‘i

Examples of these findings include:

  • A novel interaction between self-esteem and abundance of Veillonellaceae bacteria, where increased levels of this bacteria in the gut corresponded to a significant increase in self-esteem, with individuals with low self-esteem (a risk factor for depression) showing abnormally low levels of this bacteria.
  • Shared imbalance of Bacteroidetes between diabetes and obesity, where its abundance was observed to decrease with poor glycemic control and increase with obesity.
  • A significant and specific deficiency in the levels of butyrate-producing bacteria in the gut of pre- and diabetic participants, that corresponded to increased systemic inflammation.
  • A novel significant association between the levels of Cyanobacteria (which produces toxins and implicated in cancer risk in Hawaiʻi) and poor glycemic control, with overabundance of this bacteria in the gut of diabetic participants.
  • A significantly higher gut microbial diversity in obese and diabetic individuals of Native Hawaiian and other Pacific Islanders ancestry. This contrasts with the relationship observed between obesity and diabetes in other ethnic/race groups previously reported in other studies.

The new research is based on survey findings from a cohort of more than 500 Hawaiʻi residents statewide. The surveys were conducted by the University of Hawai‘i’s Hawaiʻi Social Epigenomics of Early Diabetes Cohort project and designed to identify novel biomarkers predictive of the development of diabetes in order to enable prevention and restore health equity in the islands.

The results indicate that biological findings from other ethnic/race groups may not necessarily be generalizable to the NHPI population and highlight the importance of increasing representation of NHPIs in social and biomedical research studies.

Post-baccalaureate phlebotomist Rosa Lee obtains a blood sample through venipuncture. Photo Courtesy: University of Hawai‘i

“Your gut microbiome is affected by what you eat and your environment, and for the first time, we have uncovered differences in Native Hawaiian and Pacific Islanders that contrast with findings from other populations. This may better explain higher rates of chronic health conditions such as diabetes among NHPIs (Native Hawaiians and other Pacific Islanders) that cannot be explained by social environmental factors alone,” said report co-author Alika Maunakea, associate professor at the Department of Anatomy, Biochemistry and Physiology at the John A. Burns School of Medicine.

According to the Hawaiʻi State Department of Health, Native Hawaiians and other Pacific Islanders suffer disproportionately higher rates of and deaths from type 2 diabetes than any other major race/ethnic group in the state.

In 2018, the age-adjusted diabetes death rate among Native Hawaiians and other Pacific Islanders was more than 2.5 times higher than that of the general state population. Studies have also shown that Native Hawaiians and other Pacific Islanders have a higher prevalence of depressed moods, suicidal ideation and attempts and illicit drug use, but are three times less likely to receive mental health services and treatment compared to non-Hispanic white people.


While existing research has described social determinants of mental health in this population, little is known about the biological mechanisms underlying the disproportionately higher rates of low self-esteem related to depression among Native Hawaiians and other Pacific Islanders.

“Our findings have significant implications for personalized medicine and improved strategies to enable interventions aimed at preventing chronic disease outcomes, especially among NHPIs. In working with NHPI-led community-based organizations, we are already observing some promising results of such strategies,” added co-author Ruben Juarez, HMSA Endowed Professor in Health Economics in the University of Hawaiʻi Economic Research Organization.

Sponsored Content

Subscribe to our Newsletter

Stay in-the-know with daily
headlines delivered straight to your inbox.


This comments section is a public community forum for the purpose of free expression. Although Kauai Now encourages respectful communication only, some content may be considered offensive. Please view at your own discretion. View Comments